Brain monoamine oxidases in human parkinsonian disorders
نویسندگان
چکیده
منابع مشابه
Monoamine oxidases: old friends hold many surprises
The two forms of monoamine oxidase (MAO), A and B, continue to be of major interest to biochemists, pharmacologists, neurologists, and gerontologists. Despite intensive study for more than half a century, unexpected and unique properties of these enzymes continue to come to light. Recent studies have centered on their kinetic mechanism, their unique predilection for substrates related to the ne...
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To understand the biological significance of a decreased platelet MAO activity in schizophrenia, it is important to answer many questions about the basic molecular properties of the enzyme. The past decade has witnessed a huge expansion of research in this area which has provided some of these answers. A wide variety of experimental evidence strongly supports the concept of two forms of MAO (ty...
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11973 Monoamine oxidase (MAO; EC: 1.4.3.4) is a flavin containing enzyme which exists in two subtypes, MA0 A and MA0 B. MA0 A and B are different gene products and they also differ in their substrate and inhibitor selectivities and their cellular localizations. In human brain MA0 B predominates (B:A = 4:l) and is largely compartmentalized in cell bodies of serotonergic neurons and in glia. Many...
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ژورنال
عنوان ژورنال: Brain
سال: 2017
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awx190